ABSTRACT
Objective To investigate the association between the angiotensin-converting enzyme (ACE) I/D locus polymor-phism and migraine susceptibility .Methods The case control studies on the relation between ACE I/D gene polymorphism and mi-graine susceptibility published in the databases of PubMed and EMBAE were retrieved .The relationship between ACE 1/D poly-morphism and migraine was evaluated through the effect size (OR) and 95% confidence interval(CI) by fixed-effects model or ran-dom-effect models .Meanwhile the subgroup analysis of ethnicity and migraine types was performed .Results In meta analysis ,the homozygote model(DD vs .Ⅱ:OR= 1 .21 ,95% CI:1 .02-1 .44 ,P=0 .03 ;I2 =47% ) and dominant model all indicated that the ACE I/D polymorphism was positively correlated with the susceptibility of all migraine .The heterozygote model (DI vs .Ⅱ:OR=1 .35 , 95% CI:1 .06-1 .72 ,P=0 .02 ;I2 =10% ) and dominant model (DD+DI vs .Ⅱ:OR=1 .37 ,95% CI:1 .09 -1 .73 ,P=0 .00 ;I2 =40% ) indicated that ACE I/D polymorphism significantly increased the susceptibility of migraine with aura .Conclusion The ACE I/D locus polymorphism is correlated with migraine susceptibility ,its D allele is a risk factor of migraine ,which especially increases the susceptibility of migraine with aura .